ISO-NOPNM Nitric Oxide Sensor - 100nm

The tiniest NO NanoSensor was created to monitor NO at the cellular level.

Key Features

• 0.5 pA/nM NO selectivity
• Quick reaction time: < 3 seconds
• Extremely sensitive
• For use with Apollo1000, Apollo4000, TBR4100 and TBR1025
• Requires cable 91580 (sold separate)
• Package of 3

Benefits

• The detection limit for NO is less than 0.5 nM, and the tip diameter is 100 nm

Applications

• Evaluation of NO at the cellular level

Measurement of NO at the Cellular Level

The ISO-NOPNM NanoSensor is without a doubt the tiniest and most sensitive NO sensor in the world, with a tip diameter of only 100nm (0.1 µm) and a detection limit for NO of less than 0.5nM.

NO nanosensor (ISO-NOPNM) amperometric response to injections of 2nM, 4nM, and 8nM NO into 0.1M PBS (pH=7.4).

Design

The ISO-NOPNM is based on a cutting-edge design in which the NO-sensing component is a composite graphite nanofiber that has been electrochemically "activated." A special multi-layered NO-selective membrane is subsequently used to modify the Nanosensor's surface. The ISO-response NOPNM's to adding NO at increasing concentrations of nanomolarity is shown in the figure above. The ISO-ultra-low NOPNM's noise (0.5pA) allows for a detection limit of only 0.5nM NO. ISO-NOPNM has a response time of under 3 seconds.

Selectivity of WPI's NO Sensors

Other reactive species that are expected to be present in the measuring environment shouldn't affect the NO sensor's performance. Standard Nafion-coated carbon fiber NO sensors react strongly to such species. The innovative surface membrane used by WPI's NO sensor technology amplifies the reaction to NO while suppressing responses to a wide spectrum of reactive species, such as nitrite, ascorbic acid, hydrogen peroxide, catecolamines, and many more.