Small Animal in vivo Imaging System RWD MOIS Series

The RWD MOIS Series (HTP / HT / HTX) provides high-performance in vivo imaging tailored for small animal research across various fields, including oncology, immunology, pharmacology, and stem cell studies. Featuring a back-illuminated CCD with a quantum efficiency of at least 90% and a cooling capability reaching -90°C, the MOIS system offers remarkable sensitivity for low-light scenarios. The fluorescence module is equipped with up to 26 narrowband filters and utilizes advanced spectral unmixing algorithms, enhancing accuracy and quantification in multi-color imaging. 

Accommodating a variety of imaging areas ranging from 2.5 × 2.5 cm to 25 × 25 cm, the system is versatile enough to meet both localized and whole-body imaging requirements. Integrated correction technologies—such as bias, flat-field, background suppression, and cosmic ray elimination—provide consistent and reproducible outcomes, making it ideal for high-standard workflows in in vivo research.

Advantages of RWD MOIS Series

Ultra-High Sensitivity

The CCD cooling can reach temperatures as low as -90°C, coupled with a quantum efficiency of ≥90%, which facilitates outstanding low-light performance for both bioluminescence and fluorescence imaging.

Broad Spectral Compatibility

The system supports excitation wavelengths ranging from 400 to 900 nm, accommodating a variety of fluorophores utilized in fields such as oncology, immunology, and stem cell research.

Reliable Multimodal Imaging

This system seamlessly integrates bioluminescence, fluorescence, X-ray, and Cherenkov imaging, providing a versatile solution for in vivo experimental workflows.

Quantitative Accuracy

Through calibration, spectral unmixing, and flat-field correction, the system guarantees dependable quantification throughout various imaging sessions.

Scalable Field of View

The imaging capabilities extend from 2.5 × 2.5 cm to 25 × 25 cm, making it suitable for both localized and whole-body applications.

Data Consistency

Corrections for bias, background, and cosmic rays improve image uniformity and ensure reproducibility.

Highlights of the MOIS HT Small Animal In Vivo Imaging System

• Equipped with a back-illuminated CCD camera that is depth-cooled to -90°C, effectively minimizing background noise.
• It boasts a quantum efficiency exceeding 90%, with specialized coating on the chip to guarantee high sensitivity within the 500-700nm spectrum.
• With an F/Stop of ≤ 0.95, the lens captures more photons per unit time, allowing for the acquisition of finer details with reduced noise.
• The system covers a broad wavelength range from 400 to 900 nm, making it suitable for various commonly utilized dyes and probes in scientific research applications.
• Standard equipment includes 19 excitation filters and 7 emission narrow band filters, ensuring a pure signal to prevent color crosstalk and deliver realistic data.
• The calibrated light source complies with NIST standards for absolute bioluminescence quantification, ensuring consistent results across imaging parameters.
• Uniformity in excitation light intensity guarantees consistent strength across different fields of view, thereby enhancing the reliability of fluorescence data collection.
• The field of view (FOV) is ≥ 25cm × 25cm, allowing for the simultaneous monitoring of at least 5 animals.
• It is equipped with a 5-channel anesthesia tray and active scavenging masks to prevent leakage of anesthetic gases.

Comparison of Small Animal In Vivo Imaging Systems: -70℃ vs -90℃

Additional Recommendations:

• High-Precision Imaging: The -90℃ version features significantly lower dark current and readout noise, ensuring sharper and more detailed images.
• Stability and Reliability: The reduction in dark current enhances stability, which is crucial for long-term experiments.
• Future-Proof: The -90℃ version offers long-term value for increasingly precise imaging requirements.
• Superior Low-Light Performance: It is ideal for detecting weak light signals in fluorescence and molecular imaging.

Applications of RWD MOIS Series

• Cancer
• Drug Development
• Immunity & Stem Cells
• Developmental Biology
• Neuroscience
• Genetics & Molecular Biology