Nanion's SyncroPatch 384 for All of Your Needs Involving Patch Clamps

Innovative Approaches to Advance Ion Channel Research

The SyncroPatch384 is an innovative automated patch clamp system that combines cutting edge liquid management with excellent electrophysiological data gathering and processing. Up to 384 cells can be recorded in parallel using 384 amplifier channels and a 384-pipetting head, yielding a daily throughput of up to 20,000 high-quality data points. SyncroPatch384 is much more than a fully automated HTS system because of its open design and ease of usage. It can also be effectively utilized for lower throughput applications.

Key Features:

• 384 simultaneous recordings
• Recordings with giga seals
• 20,000 or more data points every day
• Enhanced temperature regulation
• The 32-well option is ideal for modest projects
• Either one or more holes in chips
• A success rate of up to 95%
• Standard voltage and current clamp

The SyncroPatch 384 is a sophisticated liquid handling robot integrated with an automated patch clamp instrument including 384 recording channels. In addition to larger compound library screening, it can be used for smaller screens and assay development when employing the 32-well mode of operation. By doing so, the instrument can be effectively modified to operate at a lower throughput by utilizing a smaller portion of the chip and pipetting head in multiples of 32 wells. The remaining portion of the chip can be utilized over a few days, further leveraging the NPC-384 chip's low cost. A sophisticated temperature control that can both heat and cool is also included with the SyncroPatch 384. This control can be used to activate cold-activated ion channels or to maintain a consistent temperature. The SyncroPatch 384 can be applied to complicated biophysical investigation of ion channels in academic research, as well as all phases of drug discovery, from hit discovery through lead optimization to safety pharmacology.

The Biomek i5 pipetting robot, Tecella amplifier with 384 channels, NPC-384 chips, Reagent beginning kit, and the necessary software are all included in the SyncroPatch 384 system as a whole. Standard features include temperature control, cooled CellHotel, and current clamp.

Nanion's devoted staff of engineers and electrophysiologists is committed to ongoing internal assay research, software, and hardware innovations, guaranteeing prompt and specially designed solutions for your test requirements.

Effective Data Processing and Exporting

With PatchControl 384, you can quickly and easily set up voltage protocols and experimental parameters with its robust graphical user interface.

• Straightforward, simple, and intuitive experiment setup
• A large selection of QC choices
• Recording wells' color coding according to predetermined QC parameters
• The same window displays the analytic results and raw data.
• Both basic and sophisticated functioning

DataControl 384 makes it easier and faster to load recorded files and user-defined analysis templates, which speeds up data analysis.

• A few mouse clicks are all it takes to do an analysis (IC50, EC50, Z' values, Vhalf, etc.).
• Within seconds, data analysis templates show the results.
• Recalculation in real time when a parameter is changed
• Heat maps can provide a clear summary of compound impacts
• Word, Excel, CSV, and PDF reports with customized data export